I would come out going vertical and go aggressive with it (early and often). If nothing else, they will be forced to get back on their heals, and we can come right back at them with a steady dose of Williams, Hill, Brown and Lasike.
There is no reason we should not have the upper hand going into this game knowing 100% what their Defensive Game Plan is going to be. Their Defense will be focused on #4 & #21.