Oklahoma is 84-18-7 against Oklahoma, including Oklahoma winning 8 of the last 10 games in the series (2011 and 2014). In many ways they can be compared to Utah State against BYU over the last 40 years -- just not successful but have won 2 of the last 4.
Personally, I think the game comes down to Mayfield -- if Mayfield plays then Oklahoma wins, if Mayfield has to sit out then Oklahoma loses. At this point, it appears Mayfield is playing.