A Southern California native, Weddle grew up in Alta Loma, 35 miles east of Los Angeles. He and his wife, Chanel, his former high school sweetheart, married in La Jolla on July 2005. The couple has four children, Brooklyn Marie, Silver Jean, Gaige, and Kamri Joe. Eric and Chanel wed before his junior season at Utah. They lived around Ogden, Utah, to be nearer to Utah State University in Logan, Utah, where Chanel went to school and played soccer for the Aggies, while Eric commuted nearly an hour each way to Salt Lake City, where the University of Utah is located, for school and football.

Weddle is a gym-rat, an avid golfer, plays basketball, and enjoys bowling and movie nights with his family. He golfs several times a week. Weddle was a special education major at Utah who helped tutor students with learning disabilities. As a professional, he has remained active in the community supporting a number of worthy causes, including breast cancer as his grandmother is a two-time survivor of the disease.

While in college at The University of Utah, Weddle converted to The Church of Jesus Christ of Latter-day Saints.