I just missed out on the biggest real estate/financial opportunity of my middle-age life...

I'll spare the details but it was a rare opportunity that didn't work out. Normally I would tell myself better things will come along but I also know second chances don't always come along. With this opportunity, it was probably a one-time thing. Trying to cope with the frustration of it all.

Have you had opportunities that didn't ever come back that you've come to terms with? How did you do it?