I haven't been able to to hunt the last few years, but I am pretty confident out to about 400 yards.
With the new optics and bi-pods/stabilizing equipment and a 300 Mag, hunters are pretty devastating at much further distances. Kind of crazy/cool/scary actually. Hopefully the hunters are shooting for really big bucks at that distance.
Seems like too much work to have to hike/lug out a two point buck that you shot on the distant ridge.