Here's all of mine where we went through 6 states going one way:
2x KY-OH-IN-IL-WI-MN-ND-MT-WA.
1x KY-OH-WV-PA-NJ-NY to drive to NYC for work/sight-seeing.
2x KY-TN-AL-MS-LA-TX we've done to visit family.
10x KY-TN-NC-SC-GA-FL was one we did often - 2x/year when we lived in KY and my in-laws lived near Jacksonville. And that was always driven in one day.
It's a lot easier if you don't live in the west. However, if your wife's definition is R/T, I'd add probably a dozen more.