you can hardly ever tell who is who by their twitter handles.
Someone responds to someone else and has like 5 different twitter handles tagged and you can't tell who is responding to who and who the 5 people are that are tagged. So you have to click on each person one at a time and sometimes read several pages before you can tell who that person really is, the back track to the original tweet and on and on.
It's like this weird treasure hunt with clues you have to follow before you can even understand what one little 128 character tweet is talking about.