that can lift roughly the same; but 1 weighs 220 and the other weighs 280-320? That 80ish lbs difference will result in the lighter guy getting pushed all over the place. Sure he (Taysom) can outrun the other guy, but that doesn't make much of a difference in the trenches.
The other thing is that larger frame will allow you to take a lot more punishment over the course of 4 quarters. Maybe a Taysom type guy could get in a few good hits early. But over an entire game that weight difference will absolutely destroy you.