I mean take number 1 for example. Defense plays 5 under and you got a corner and 2 lbs sitting on your curl routes. Your toast. Sack or int city.

Now if your smart your going have your qb change play at line pre snap, but if not your going give your receivers an option if they see that defense they will change there routes and your qb can read/move the safety and hit the post corner route instead.