Option 1: Drive to airport that is 70 min away (2 hrs 20 min RT drive). Nonstop flight that is 4 hrs 40 min each way, roughly.

Option 2: Drive to airport that is 25 min away (50 min RT). Layover in Detroit is 1 hr going out. Layover in Chicago (O'Hare) is 1.5 hours coming back. Travel time is 6.5 hours each way, roughly.

Assume airfare cost and airline/seating is the same for both options. Also assume arrive and departure times are no problem in either case.