UTEP over BYU in 1985
Utah over Stanford last year
Virginia over BYU last year
Indiana over Missouri @ Missouri this year
Yeah, it'd be an upset. But there have been MUCH bigger upsets including this year.
USU is a 17 point underdog (give or take). A quick google for big upsets gave me Stanford over USC in 2007. The point spread? 41 in favor of USC.