Working for the state - I'd been there for a couple of years and there had never been any kind of drug testing. We get notification that every employee is going to be required to be drug tested, and that random drug testing would continue after that.

One guy, who was relatively new, stayed late to work and wrote an epic email about how stressful the job is, how difficult it is, how he just can't take it any more, and then resigns in said email. Which he promptly sent to the division director, along with all 1,000+ people who worked for that division.

About 4 weeks later another coworker went to a street fair and ran into him at a booth selling hemp products.