You think his big man is going to be 6'7"? You think he's going to have 6' white kids at point guard? Pope won games with THOSE kids; I'm fairly sure he can win with a roster full of lottery picks.
His system is uptempo and fun, his kids play hard and work on defense, and his leading rebounder isn't going to be Spencer Johnson next year. I don't see any reason he can't win at UK.
P.S. Calipari lost because his teams were undisciplined and unfocused. Pope will have to do better with that, but if he does, he'll win. And he'll win a lot.