With two 10-team divisions, you play nine division games and just three non-division games. How many of them have to be against the other division? Do you only count division games for standings? I think 0-1 and yes are the best answers there, but it gets tougher to navigate with more teams.

If I had dictatorial power over college football, I would probably go with 6 12-team conferences - PAC12, Mountain-Plains 12, Big 12, SEC, ACC, Atlantic 12 (or something like that). Let's see:

PAC12: Washington, Wazzu, Oregon, Oregon State, Stanford, Cal, USC, UCLA, Arizona, Arizona St., Utah, Boise State
Big 12: Minnesota, Wisconsin, Iowa, Iowa State, Illinois, Northwestern, Indiana, tOSU, Michigan, Michigan State, Purdue, Notre Dame
Mountain-Plains 12: BYU, Colorado, Kansas, Kansas State, Oklahoma, Oklahoma State, Texas Tech, Texas, Baylor, TCU, Mizzou, Nebraska
SEC: Texas A&M, Houston, Arkansas, LSU, Ole Miss, Mississippi State, Alabama, Auburn, Georgia, Georgia Tech, Florida, UCF
ACC: Florida State, Miami, USF, Clemson, South Carolina, North Carolina, NC State, Wake Forest, Duke, Virginia, Virginia Tech, Maryland
Atlantic 12: Penn State, Pittsburgh, Syracuse, Rutgers, Boston College, West Virginia, Kentucky, Louisville, Cincinnati, Tennessee, Vanderbilt, Memphis

16-team playoff, conference champs get autobids, top 10 non-champs in Massey composite get at-large bids, conferences negotiate their own TV agreements, but with a fair-play stipulation that requires a percentage of TV revenues to be shared among everyone to avoid monetary imbalances getting too large. Done.