I have many. I'm a reloader, and I discovered that it makes way more sense to pick a caliber and stick with it. I chose the 6.5 CM and the .30 Nosler. I have both a target gun and a hunting rifle in .30 Nosler. I have four 6.5 CM's. One is an ultra-light weight hunting rifle. One is a right hand bolt, left hand ejection port bench rifle. One is a hybrid long range tactical setups. One is a JP Enterprises AR style rifle.
I'm not wedded to any particular caliber, though. There are advantages and disadvantages to most of them.
I love shooting my 22-250. I also love shooting a .17 HMR. I just got rid of my .270 (converted it to the 6.5 CM hunting rifle). I'd like to get rid of my .308 to make room in the safe - I just don't shoot it anymore. I have a 7mm-08, which is a great deer hunting round, but I don't see myself using it over the 6.5 CM at this point. I used to have a .300 RUM, but I got rid of that when I built the 30 Nosler hunting rifle.