From the State Department:

Jalisco state – Reconsider Travel

Reconsider travel due to crime.

Violent crime and gang activity are common in parts of Jalisco state. In metropolitan Guadalajara, battles for territory control between criminal groups take place in areas frequented by U.S. citizens. Shooting incidents between criminal groups have injured or killed innocent bystanders.

U.S. government employees may not travel to:

Within 20 km (12 miles) of the Jalisco/Michoacán border, south of Route 120
Highway 80 south of Cocula
Highway 544 from Mascota to San Sebastian del Oeste