BYU had rolled through the most difficult parts of their schedule (Including the W v. Texas that put them on everyone's radar) with really only Boise left on the schedule that looked like a potential loss. Then Taysom went down and it was game over. Definitely a big what-if moment for that season.
But I am a Utah fan, so my opinion is tainted and there just isn't the same emotion with BYU losses. But yeah, that one is really high up there because of the impact Taysom's injury had on the season.