supposed to be adjusting their blocking on the fly and you can make any hole on the side of the line where the run is called open up, i.e. could be the 1, 3, 5 or 7 hole. the OL is supposed to react to the DL blocking scheme, and the RB needs to recognize which hole that develops into and then cut and burst through it.
When the OL doesn't give the RB a hole to run through because they aren't reading the DL blocking the same way and so everyone is washing, you have no holes to run through, thus the 65th best (worst) run blocking OL.