This drug changes how things in your body work and taking it for so long seems like it could cause long term damage to how functions are supposed to work. I only think about it this way after watching how the show "Biggest Loser" ended up wrecking some contestant's metabolisms permanently due to the drastic changes/shock that happened in their bodies (who knows if they took medication too?). Maybe I'm off base. I've had several friends and coworkers have awesome results on Ozempic and they seem happy so I'm happy for them too.