It didn't affect her too much, but it definitely seemed to help keep the other two in.

But our situation was different in that it was to keep Prego instead of get there in the first place. My wife likes to know a lot on this type of stuff (she is not medically trained in any way) and she said that maybe your wife is getting too much so maybe talk to docs about testing levels and lowering? Or the method of delivery changing? she got hers via shot in the rear. Also, she thinks that when you use it get pregnant you often stop after 16 weeks.

Again, my wife is not medically trained, just researched a lot for herself, so talk to your doc and maybe the above give you some additional talking points or questions to bring up. Maybe it doesn't help at all. Sorry it's been so rough for her. Good luck.