Large RCTs with endpoint of all cause mortality. We already know safety profile of the drugs, so it is much easier to do trials.

I'm a physician. But, don't take my word for it. Pretty much every infectious disease specialist in Utah signed a letter this week to the Utah Medical Association recommending to only prescribe these drugs inside of clinical trials for Covid-19. When UofU and Intermountain have released their data that shows positive outcomes on all cause mortality, then I will become Very excited.