The Spirit experience is budget, so like Allegiant, Frontier, Ryanair, etc. you
only want to do it if you pack light. Sometimes you can upgrade to extra legroom for not too much. Since they fly into Vegas from everywhere, it's fairly convenient (I live in Indiana and have made the flight to Vegas several times).
I've had plenty of decent and bad experiences on enough airlines that I usually shop on price unless I'm traveling alone or someone else is paying. Allegiant from Wichita to Mesa was horrible, but between Austin and Indianapolis was amazing. I've been stuck overnight in Chicago on American, and had flights canceled entirely on United. I figure the risk of getting stuck is similar regardless. On short flights I'll take the uncomfortable seat for a couple of hours to save a hundred bucks.
I haven't experienced Ryanair, but plan to in the next few years. I want to check more countries off, so with a 10 day vacation somewhere I will spend a week but try somewhere else for a weekend. I'm amazed at how cheap their flights are and wonder why we don't have something like it here.