because, apparently, participants know for sure what they took, LOL
Also, some of the studies advertise to people who might be fully primed to have a "spiritual experience". Are you open to trying a psychedelic for spiritual purposes? Come try our study!
Very hard to know how to be academically rigorous.
Also, last time I checked, the rave crowd doesn't all the sudden come around having excellent mental health. So, I think set/setting must be just as important as the substances themselves. And if that's the case, is it even the substances at all? Etc. You get it.