Agree SARS-CoV2 doesn't cause hemolysis directly, though multi-organ failure with DIC will. Likely mechanism of action

Apr 8, 2020
10:43:23am

SaturdaySpecialDay Q Hall 5th floor

of hydroxychloroquine (Plaquenil) is similar to its benefit in autoimmune disease - reduces production of pro-inflammatory cytokines (ie blunts the "cytokine storm") via its effect on T cells, macrophages, and other factories of IL-6, TNF, etc.

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SaturdaySpecialDay

Bio page: SaturdaySpecialDay
Joined: Aug 21, 2013
Last login: May 20, 2024
Total posts: 5,703 (2,250 FO)

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Messages

Author

Time

The more I read, the more I'm convinced that Covid 19 isn't primarily

slowhiteguy

4/8/20 10:05am

It seems like the medical community would be able to prove or disprove that

darkcoug

4/8/20 10:06am

If true I’m not sure what to make of those doing the research.

Coach's Dad

4/8/20 10:10am

The more I read, the more I'm convinced I'm an idiot & should stay in sales.

The Y's Insider

4/8/20 10:15am

Don't feel bad. Biology was never my strong suite, either. That's why I'm a.....

BleedCougarBlue2

4/8/20 1:19pm

What is your background and what made you reach that conclusion?

yerromnitsuj

4/8/20 10:16am

Anesthesia, currently work in medical affairs for a respiratory and vent

slowhiteguy

4/8/20 10:21am

Are there other professionals who share your opinion?

yerromnitsuj

4/8/20 10:35am

Be sure to fire off an email CC'ing all the medical researchers to let them know

ReyOso

4/8/20 10:16am

No need. It is already being discussed. But I appreciate your condescending

slowhiteguy

4/8/20 10:20am

It may be so, but who knows? I'm no more a medical expert than you are.

ReyOso

4/8/20 10:27am

So you have more than 20 years working in the field and have a D degree?

slowhiteguy

4/8/20 10:33am

How dare you! He's the resident assistant to the resident self/proclaimed expe

whirl

4/8/20 1:14pm

Man, I enjoyed that. Thanks SWG for shutting him up and the info passed on.

TheismanHill1911

4/8/20 1:47pm

RE: So you have more than 20 years working in the field and have a D degree?

fredetteaboutit13

4/8/20 2:16pm

SWG is more of a medical expert than you are. More than the vast majority of the board. In

unctoothman

4/8/20 10:39am

You sir should be arrested.

Scrog

4/8/20 10:58am

RE: SWG is more of a medical expert than you are. More than the vast majority of the board. In

YIsForBrigham

4/8/20 11:04am

RE: SWG is more of a medical expert than you are. More than the vast majority of the board. In

mightybrick

4/8/20 11:31am

Boy, anyone who’d been owned that thoroughly I’d have to think would deactivate

Nikomedes

4/8/20 1:18pm

RE: Boy, anyone who’d been owned that thoroughly I’d have to think

IceCreamButt

4/8/20 1:40pm

RE: SWG is more of a medical expert than you are. More than the vast majority of

buhlcougar

4/8/20 2:10pm

Um, SWG is quite a knowledgeable guy here. I would walk back your criticism...

Ragnar Danneskjold

4/8/20 10:55am

Does that happen on CB? Is it even allowed? 🙂

Northwest Cougar

4/8/20 10:58am

Definitely against board rules.

CougarThug

4/8/20 1:09pm

<< Deleted >>

Romex

4/8/20 11:20am

still hasn't reached influenza levels, yeah, people think it has but it isn't

gilmerbuckeye

4/8/20 12:12pm

Really, on a case per month it's much higher isn't it?

charles

4/8/20 12:39pm

On a per-day basis it has.

redraider88

4/8/20 1:16pm

Right now we’re sitting around 1300/day, give or take. If that keeps going for,

Jay Rick

4/8/20 4:43pm

Thanks SWG, I'm grateful for your insight.

AingeEraCoug

4/8/20 11:09am

I wish I could have seen that. My NYC contacts are pretty much text

slowhiteguy

4/8/20 11:22am

I wish I could retrieve it

AingeEraCoug

4/8/20 12:33pm

I'd wager $50 he never comes back and apologizes. Sad.

BleedCougarBlue2

4/8/20 1:22pm

Very reassuring way to encourage discussion. Well done. This will surely help people take you seriously.

mightybrick

4/8/20 10:28am

Can you share what you’re reading?

Y'zcrack

4/8/20 10:24am

This was being passed around last week between a group of my collegues.

slowhiteguy

4/8/20 10:46am

I can’t speak for what other research you’ve read, but this paper shouldn’t be

ldssdl

4/8/20 11:53am

Anything from a "xiv" site is pre-print and not peer-reviewed

bythenumbers

4/8/20 12:22pm

Not peer reviewed and the article isnt perfect by any means.

slowhiteguy

4/8/20 12:36pm

Thanks, I'll check it out.

Y'zcrack

4/8/20 1:56pm

The only research I could find on the subject was not peer reviewed and had

doctorcoug

4/8/20 10:37am

At this point, how much peer reviewed research will exist on this topic? You know

unctoothman

4/8/20 10:51am

I'm not asking for peer review. What I'm saying is the foundation of their

doctorcoug

4/8/20 10:57am

Again, it is interesting. I know of two reputable institutions that are

slowhiteguy

4/8/20 11:00am

Love to hear what is found. The idea that this theory sounds plausible is quite

doctorcoug

4/8/20 11:09am

That is why this is such a crazy illness. It is confusing. I will circle back

slowhiteguy

4/8/20 11:11am

Yes, please share.

Y'zcrack

4/8/20 1:48pm

No question it has flaws. But at least they are willing to look for

unctoothman

4/8/20 11:19am

There is certainly holes in the theory and need for further research.

slowhiteguy

4/8/20 10:54am

Is there a theory on why there's a 2:1 male/female infection rate?

Division Bell

4/8/20 11:03am

Not that I have seen. This really is such a baffling illness. There will be a

slowhiteguy

4/8/20 11:10am

Thanks.

Division Bell

4/8/20 11:24am

In general, females have a stronger immune response than males

Y'zcrack

4/8/20 1:53pm

I don't see a single article on PubMed about hemolytic anemia

WorfoSAUR

4/8/20 10:38am

Agree SARS-CoV2 doesn't cause hemolysis directly, though multi-organ failure with DIC will. Likely mechanism of action

SaturdaySpecialDay

4/8/20 10:43am

The hypothesis isn't that it causes hemolysis. They believe that the virus binds

doctorcoug

4/8/20 10:47am

Wait, isn't that just the beginning steps of the scientific method?

Northwest Cougar

4/8/20 11:15am

They did their testing first, then came up with a hypothesis. It was so bad it

doctorcoug

4/8/20 11:41am

Speaking solely on the scientific method in general (and not on this study in particular), it is not bad science at all

dilbert

4/8/20 2:13pm

Bad science that still might elucidate useful information and findings.

unctoothman

4/8/20 11:20am

Most accurate snippet on the science of Coronavirus I’ve read on CB to date

ldssdl

4/8/20 11:57am

Interesting. Thanks for the post.

Division Bell

4/8/20 10:46am

Couldn’t Classic blood analysis easily identify if this was occurring by

yerromnitsuj

4/8/20 11:27am

The theory isn't that it is causing hemolysis. The theory is that the virus is

doctorcoug

4/8/20 11:42am

Can that not be identified with a blood test? Sorry, not a medical guy.

yerromnitsuj

4/8/20 11:45am

RE: The theory isn't that it is causing hemolysis. The theory is that the virus

redraider88

4/8/20 1:23pm

Maybe that’s why it’s not as bad in Africa

Jericho

4/8/20 12:31pm

It definitely is a respiratory disease.

redraider88

4/8/20 1:13pm

I don't doubt that researchers will learn a lot more about this bug. I've read about other thoughts regarding

CalGTR

4/8/20 1:31pm

I read an article that said the same thing. The tip off was that pneumonia

travelcoug

4/8/20 2:51pm

That’s some great insight/theory. Thanks for your post. Hopefully it leads to

bigbossbyu

4/8/20 3:37pm

Wouldn't surprise me. As a society, we knew very little about this virus.

Hill4Heisman

4/8/20 3:58pm

If this is true, does this mean that monitoring SPO2 levels with a pulse oximeter can be helpful

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