What makes the EU feasible, IE - Open Borders, Export of Goods and Services/People, Single Monetary Instrument. There is already infighting dealing with monetary policy which will only exacerbate the political disagreements with member nations. We aren’t talking states disagreeing with other states here...we are talking long standing grudges between two homogeneous groups of people that will cause the whole thing to collapse in on itself.
The US will easily bounce back more readily than the EU from this...and it will be difficult here. In the EU, this is disastrous. The UK was smart in getting out when they did.